Big game hunting is a fantastic proposition, from deer to elk to moose to hippo to elephant, but the true rarities—the mythological beasts—that require a serious time investment to find, and an even more serious financial investment are the ultimate hunting adventure.
The .375 bore is the legal minimum for dangerous game in many African countries, and with good reason: it generates just over 4,000 ft.-lbs. of energy at the muzzle, and offers a bullet with enough Sectional Density to get the job done, and done well.
The .470 Nitro Express has proven itself as a perfect choice for truly large game for more than a century now, and it won't be going away anytime soon.