Deer rifles and the cartridges loaded in them have run the gamut the last 50 years, from the Winchester 94 in .30-30 Win. to the Weatherby Mark V in .30-378 Wby. Mag. and the DPMS ARL in 6.5 Creedmoor.
When it comes to power cartridges loaded with bullets that can get the job done, even when shot angles are less than ideal, hunters have never had it so good.
Admittedly, in the final analysis, cost and availability are not big factors in my deer hunting cartridge selection. But they are factored into the equation.